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Agilent Technologies Inc.. (6/17/14). "Press Release: Agilent Technologies Introduces Innovative LC Columns, Biocolumns". Santa Clara, CA.

Products Product AdvanceBio Glycan Mapping column
  Product 2 Poroshell 120 HPLC column
Persons Person Jones, Anne (Agilent 201207 General Manager at Chemistries Division)
  Person 2 Berg, Susan (Agilent 201311–201410 Global Public Relations Life Sciences/Chemical Analysis Group LEFT 10/14)

New Glycan Mapping and Small-Molecule Poroshell HPH Columns Target Challenging Biotherapeutic Research, High-Performance pH Applications

Agilent Technologies, Inc. (NYSE: A) today introduced new columns in both the small-molecule ultra-high performance liquid chromatography and biopharma (large-molecule) categories.

The AdvanceBio Glycan Mapping Column is the latest addition to the AdvanceBio family of columns; it is specifically designed to deliver fast, high-resolution glycan separations. Poroshell HPH-C18 and Poroshell HPH-C8 chemistries are additions to the Poroshell 120 family; they are ideal for high-pH applications. These application-specific LC columns help increase laboratory throughput and provide rapid, reproducible, high-resolution results for critical applications.

"Glycan mapping is one of the more complex workflows in the development of biotherapeutics, biosimilars and biobetters," said Anne Jones, general manager of Agilent's Chemistries Division. "Accuracy and speed are of utmost importance, so in the race to bring new biotherapeutics to market, finding a faster way to get accurate results is paramount."

"Small-molecule pharmaceutical labs using high-pH method development also face unique challenges and must optimize pH stability in order to develop the most effective separation method possible," she added.

AdvanceBio Glycan Mapping Columns

AdvanceBio Glycan Mapping columns enable laboratories to complete high-resolution glycan mapping separations in less than 10 minutes. They are available in two UHPLC configurations: 2.7 µm superficially porous particles for high resolution and low backpressure (stable to 600 bar), and 1.8 µm for highest resolution, stable to 1200 bar.

Poroshell HPH-C18 and Poroshell HPH-C8 Columns

Agilent's Poroshell 120 columns are very popular with laboratories working with small molecules. New Poroshell HPH-C18 and HPH-C8 chemistries are made by chemically modifying Poroshell 120 particles using a proprietary process to increase pH stability. These columns are now the only superficially porous columns on the market that have organically modified silica support for high-pH analyses.

Superficially porous particle technology, first introduced by Agilent, provides analytical resolution similar to sub-2 µm particles, with significantly less backpressure, enabling rapid LC on any HPLC or UHPLC instrument. The new HPH chemistries enable chromatographers to develop screening methods using chemistries for low-, moderate- and now high-pH conditions without impacting column lifetime.

"Agilent has developed both products from the ground up, to ensure end-to-end manufacturing precision and high QC rigor to deliver the reproducible performance that is a hallmark of these market-leading LC columns," said Jones.

About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is the world's premier measurement company and a technology leader in chemical analysis, life sciences, diagnostics, electronics and communications. The company's 20,600 employees serve customers in more than 100 countries. Agilent had revenues of $6.8 billion in fiscal 2013. Information about Agilent is available at

On Sept. 19, 2013, Agilent announced plans to separate into two publicly traded companies through a tax-free spinoff of its electronic measurement business. The new company is named Keysight Technologies, Inc. The separation is expected to be completed in early November 2014.

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Susan Berg
+1 408 553 7093

Record changed: 2016-03-19


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