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Agilent Technologies Inc.. (7/15/15). "Press Release: Agilent Technologies Presents Thought Leader Award to Renowned Systems Pharmacologist Lawrence Lesko". Santa Clara, CA.

Region Region Orlando, FL
  Country United States (USA)
Organisation Organisation University of Florida, College of Pharmacy (Orlando)
  Group University of Florida
Products Product hybrid Quad-ToF (QTOF) mass spectrometer
  Product 2 Mass Profiler Professional software
Index term Index term Univ Florida–Agilent: grant, 201507– Thought Leader Award to Lawrence Lesko at College of Pharmacy for biomarker research
Persons Person Lesko, Lawrence J. (Univ Florida 201507 Director of Center for Pharmacometrics + Systems Pharmacology)
  Person 2 Benefiel, Monty (Agilent 201506 Division General Manager Mass Spec before 201302 VP for gas phase systems)

Award Supports Search for Biomarkers to Better Predict Side Effects of New Medicines

Agilent Technologies Inc. (NYSE: A) announced today that Dr. Lawrence J. Lesko has received an Agilent Thought Leader Award in support of his research into preclinical toxicological assessments of new medicines.

An internationally recognized pharmacologist, Dr. Lesko directs the Center for Pharmacometrics and Systems Pharmacology at the University of Florida's College of Pharmacy in Orlando.

"We are pleased to support Dr. Lesko's research, which is addressing important needs in the rapidly evolving field of systems toxicology," said Monty Benefiel, Agilent vice president and general manager of the Mass Spectrometry Division. Benefiel is the executive sponsor of this award.

Dr. Lesko and his team are using Agilent accurate mass Q-TOF LC/MS to collect and analyze metabolomics data. With the help of Agilent's Mass Profiler Professional and Pathway Architect software, they hope to discover biomarker panels that could enable the development of future companion diagnostics.

"I am very pleased and appreciative of Agilent's Thought Leader Award," said Dr. Lesko. "It enables our team to identify metabolomic safety biomarkers of drug-induced renal toxicity and the mechanisms by which these toxicities occur. This research will lead us to identifying at-risk patients and exploring the use of concomitantly administered medicines as protectants against drug-induced renal damage. It could have a major effect on improving drug development and clinical care."

Kidney toxicity is a leading cause of formerly approved drugs being withdrawn from the market. Although a few clinical biomarkers of kidney injury are available, they lack adequate sensitivity or specificity. Dr. Lesko and his team want to identify novel biomarkers that could not only help drug makers better assess new drug candidates but might eventually enable doctors to better manage treatments.

The Agilent Thought Leader Award promotes fundamental scientific advances by contributing financial support, products and expertise to the research of influential thought leaders in the life sciences, diagnostics and chemical analysis. Information about previous award recipients is available at Agilent's Thought Leader website.

About Agilent Technologies

Agilent Technologies Inc. (NYSE: A), a global leader in life sciences, diagnostics and applied chemical markets, is the premier laboratory partner for a better world. Agilent works with customers in more than 100 countries, providing instruments, software, services and consumables for the entire laboratory workflow. The company generated revenues of $4.0 billion in fiscal 2014 and employs about 12,000 people worldwide. Agilent marks its 50th anniversary in analytical instrumentation this year. Information about Agilent is available at

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Record changed: 2016-01-10


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