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Dionex Corporation. (10/00). "Press Release: Dionex Demonstrates a Single HPLC Assay Method to Accurately Determine Four Key Anti-tuberculosis APIs". Sunnyvale, CA.

Organisation Organisation Dionex Corporation
  Group Thermo Fisher (Group)
Products Product UltiMate® 3000 LC system (product series)
  Product 2 liquid chromatography column (LC column)
     


Dionex is proud to announce a single high-performance liquid chromatography (HPLC) method that can be used to assay the four active pharmaceutical ingredients (API) (i.e., isoniazid, pyrazinamide, rifampicin, and ethambutolare) in combination drug tablets commonly used to treat tuberculosis (TB). Application Note 257: HPLC Assay Method for Drug Products Containing Anti-Tuberculosis Active Pharmaceutical Ingredients demonstrates a ten min method that saves time and reduces mobile phase consumption and waste, compared to the two HPLC assay methods described in the United States Pharmacopeia (USP) monograph. Further savings and waste reduction are possible with an ultra HPLC (UHPLC) method that requires less than 2 min per injection.

Using the Dionex UltiMate® 3000 system and Acclaim® Polar Advantage II column, this approach accurately determines all four compounds of interest in drug products commonly used to treat TB. The analysis of two drug products yields acceptable percentage contents, as judged by the limits in the USP monograph. In addition, an accelerated UHPLC method is available for high-throughput sample analysis.

Dionex (NASDAQ:DNEX) is a global leader in the manufacturing and marketing of liquid chromatography and sample preparation systems, consumables, and software for chemical analysis. The company's systems are used worldwide in environmental analysis and by the life sciences, chemical, petrochemical, food and beverage, power generation, and electronics industries. Our expertise in applications and instrumentation helps analytical scientists to evaluate and develop pharmaceuticals, establish environmental regulations, and produce better industrial products.

Acclaim and UltiMate are registered trademarks of Dionex Corporation.

   
Record changed: 2016-03-19

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