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CovalX AG. (11/30/10). "Press Release: The European Patent Office Grants ETHZ and CovalX a New Patent for Protein Interaction Analysis by MALDI Mass Spectrometry". Zürich.

	Region	Europe
	Organisation	CovalX AG
	Group	CovalX (Group)
	Organisation 2	ETH Zürich (ETHZ)
	Product	MALDI technology
	Product 2	mass spectrometry solution/method
	Index term 2	CovalX–ETH Zürich: protein sample preparation, 201006– license ww excl to CovalX + before co-developm of cross-linking molecules with ETHZ + ABI

The European Patent Office has granted a European Patent (06 721 947.7) to the Swiss Federal Institute of Technology (ETHZ, Zürich) and CovalX AG (Schlieren), claiming for the use of chemical cross-linking in combination with MALDI mass spectrometry for the direct analysis of protein-protein interactions.

The method of the invention allows the direct analysis of non-covalent complexes in a very broad mass range (currently up to 2 MDa) with nM sensitivity. The method can be applied in most formulation and experimental buffers and allows to characterize the stoechiometry of any protein-protein interaction, with the accuracy of mass spectrometry.

The method takes benefits of specially developed cross-linking molecules, allowing fast and efficient stabilization of the non covalent complexes and a unique high-mass detection system allowing nM detection of the complexes up to 2 MDa.

The Method has been supported by more than 20 peer reviewed scientific articles coming from a large number of renowned institutes arround the world. Direct analysis of hydrophobic protein complexes, therapeutic protein aggregates or inhibitors of protein interaction are now possible using the patented method.

Record changed: 2011-11-25

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CovalX AG. (11/30/10). "Press Release: The European Patent Office Grants ETHZ and CovalX a New Patent for Protein Interaction Analysis by MALDI Mass Spectrometry". Zürich.

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