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JEOL USA, Inc.. (10/25/12). "Press Release: Maintaining High Mass Resolution for Tissue Imaging with the JEOL SpiralTOF". Peabody, MA.

Organisation Organisation JEOL USA Inc.
  Group JEOL (Group)
Products Product SpiralTOF™ mass spectrometer (product series)
  Product 2 mass spectrometry imaging (MSI) (MALDI imaging)
Person Person Corkum, Patricia (JEOL 200903 Marketing Manager JEOL USA)

A new application note from JEOL demonstrates that high mass resolving power can be maintained for matrix-assisted laser desorption ionization (MALDI) imaging of biological specimens by using a TOF system with a very long flight path.

The JEOL SpiralTOF MALDI TOF/TOF mass spectrometer has unique multi-turn ion optics that pack a 17-meter flight path into a compact 1-meter mass analyzer. The instrument is capable of a resolving power of >60,000, the highest resolving power commercially available in a MALDI-TOF system. When equipped with the MS/MS option, the SpiralTOF is the only TOF/TOF system capable of monoisotopic precursor selection.

One consequence of the long flight path is that topographic differences in the sample have little effect on the measured mass spectrum. "In other words, the SpiralTOF can maintain high mass resolution and high mass accuracy while imaging, even if the sample is not flat," said Dr. Robert (Chip) Cody, Mass Spectrometry Product Manager at JEOL. This was also demonstrated in an earlier applications note describing the relationship between crystal condition and mass resolving power and accuracy.

A study carried out by JEOL Ltd. in collaboration with the Mass Spectrometry Group in the Department of Physics, at the Graduate School of Science of Osaka University used MALDI imaging to examine a section of mouse brain. Because of its long flight path, the SpiralTOF was able to create images showing separate spatial distributions for two phospholipids with masses that differed by only 90 millimass units!

The new tissue imaging application note and more than 20 additional SpiralTOF notes can be downloaded at

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JEOL is a world leader in electron optical equipment and instrumentation for high-end scientific and industrial research and development. Core product groups include electron microscopes (SEMs and TEMs), instruments for the semiconductor industry (electron beam lithography and a series of defect review and inspection tools), and analytical instruments including mass spectrometers, NMRs and ESRs.

JEOL USA, Inc., is a wholly owned subsidiary of JEOL, Ltd., Japan, was incorporated in the United States in 1962. The company has 13 regional service centers that offer unlimited emergency service and support in the U.S.

For more information about JEOL USA, Inc. or any JEOL products, visit, or call 978-535-5900.

Patricia Corkum, Marketing Manager
978-536-2273 o o

Record changed: 2016-03-19


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