Advertisement

Picture AB Sciex Berliner LCMSMS Symposium 2017 Middle 600x60px
Document › Details

Waters Corporation. (9/1/09). "Press Release: American Chemical Society Awards John R. Engen for Scientific Achievements. Prof. Engen Investigates Protein Confirmation Using Novel Hydrogen/Deuterium Exchange Technique on Waters Synapt High Definition MS

Region Region United States (USA)
Organisations Organisation Waters Corporation (NYSE: WAT)
  Group Waters (Group)
  Organisation 2 Northeastern University, Barnett Institute for Chemical and Biological Analysis
  Group Northeastern University (Boston)
Products Product hydrogen-deuterium exchange technology (H/D exchange technology)
  Product 2 Synapt™ HDMS system
  Index term 2 Waters–Northeastern Univ: H/D exchange technology, 2007– collab developm H/D exchange technology on Synapt High Definition MS for proteomics
Person Person Engen, John R. (Northeastern Univ 200909 Prof at Barnett Institute for Chemical and Biological Analysis)
     


Waters Corporation (NYSE: WAT) announced today that the Analytical Chemistry Division of the American Chemical Society presented Prof. John R. Engen of Northeastern University with the Arthur Findeis Award for Achievements by a Young Analytical Scientist. Through a collaboration with Waters Corporation, Prof. Engen has pioneered the combined use of hydrogen-deuterium (H/D) exchange technology, UltraPerformance LC(R) and ion mobility mass spectrometry to better understand the conformation, or the folded three-dimensionality, of proteins that are thought to play a major role in some diseases. Prof. Engen received his award at a ceremony at the ACS National Meeting in Washington on August 16.

By being able to form a better three-dimensional picture of these proteins and how they move and react with other proteins, scientists are able to better understand the relationship between protein function and protein structure and, it is hoped, gain new perspectives on how diseases begin and progress. Prof. Engen is an Associate Professor of Chemistry & Chemical Biology and a Faculty Fellow at Northeastern University's Barnett Institute of Chemical and Biological Analysis.

Proteins are carefully structured, three-dimensional, long-chain molecules that when properly folded regulate normal bodily functions. Several high profile diseases including Alzheimer's, Creuzfeldt-Jakob's, and Parkinson's can develop when certain proteins become misfolded, causing a chain of events that can lead to disease symptoms. Thus understanding how a protein achieves its folded state is important. Mass spectrometry is unique in its ability to monitor individual proteins and protein complexes.

Prof. Engen has published extensively on the H/D technique, most recently in the Proceedings of the National Academy of Sciences, and in a feature article for Analytical Chemistry. Waters and Prof. Engen's laboratory at the Barnett Institute for Chemical and Biological Analysis entered into a scientific collaboration in 2007. To further Prof. Engen's experimental technique, Waters engineers constructed a specially-designed programmable cooling chamber for the Waters(R) nanoACQUITY(R) UPLC System, recently described in Analytical Chemistry.

Waters introduced the SYNAPT(TM) High Definition MS (TM) (HDMS(TM)) System at the American Society of Mass Spectrometry annual meeting in Seattle in June of 2006. It is the first commercially-available mass spectrometer with the ability to analyze ions by their size, shape and charge in addition to mass.

About Waters Corporation

Waters Corporation creates business advantage for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety and water quality worldwide. Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success. With revenue of $1.58 billion in 2008 and 5,000 employees, Waters is driving scientific discovery and operational excellence for customers worldwide.

Waters, SYNAPT, UPLC, UltraPerformance LC, nanoACQUITY, HDMS, and High Definition MS are trademarks of Waters Corporation.

Brian J. Murphy of Waters Corporation, +1-508-482-2614, brian_j_murphy@waters.com

   
Record changed: 2016-03-19

Advertisement

Picture EBD Group BIO-Europe Spring 2017 BES Barcelona Spain March 600x60px

More documents for Waters (Group)


To subscribe to our free, monthly mass spectrometry newsletter, please send an e-mail to info@iito.de and simply fill the subject line with the word »MSC newsletter«

To get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]

Please visit also our web portals for the Eurpean life sciences and the life sciences in German-speaking Europe (DE, AT & CH) at Life-Sciences-Germany.com and Life-Sciences-Europe.com

Advertisement

Picture Fairtec GmbH Worldwide Event Solutions 600x60px




» top

Advertisements

Picture [iito] Twitter iitoLifeScience Life Sciences Mass Spec 120x120px BCNP Consultants European Chemistry Partnering 2017 Ffm Germany 120x180px Picture EBD Group BIO-Europe Spring 2017 BES Barcelona Spain March 120x180px Picture AB Sciex Berliner LCMSMS Symposium 2017 Right 120x80px Picture [LSE] Life-Sciences-Europe.com – The Business Web Portal 120x600px Banner Fairtec GmbH Solutions for Smarter Business Events Exhibitions 120x120px Picture [iito] Twitter iitoLifeScience Life Sciences Mass Spec 120x120px