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Agilent Technologies Inc.. (10/21/09). "Press Release: Institute for Systems Biology, Agilent Technologies to Build MRM Atlas for Quantification of All Human Proteins". Seattle, WA & Santa Clara, CA.

Organisation Organisation Institute for Systems Biology (ISB) (Seattle)
Products Product MRM Atlas (Human Multiple Reaction Monitoring Atlas)
  Product 2 LC/MS system
Persons Person Hood, Leroy (Lee) (Institute for Systems Biology)
  Person 2 Aebersold, Ruedi (ETH Zurich 2005c– Professor Systems Biology before Institute of Systems Biology Seattle)

The Institute for Systems Biology (ISB) and Agilent Technologies Inc. (NYSE: A) today announced a collaboration to create the Human Multiple Reaction Monitoring (MRM) Atlas, a comprehensive resource designed to enable scientists to perform quantitative analysis of all human proteins. The project is expected to fuel important research gains in biomarker discovery and validation, the search for protein-based diagnostic tests, personalized medicine, and human health monitoring.

The program is supported by grants totaling $4.6 million to ISB's Robert Moritz and Leroy Hood for developing the "Complete Human Peptide and MRM Atlas" by the National Human Genome Research Institute of the National Institutes of Health, under "The American Recovery and Reinvestment Act - Grant Opportunities." Ruedi Aebersold of the Swiss Federal Institute of Technology (ETH) Zurich is collaborating as well, with additional funding from the European Research Council.

The work, occurring over two years, will be performed using Agilent triple quadrupole and quadrupole time-of-flight liquid chromatography/mass spectrometry (LC/MS) systems and nanoflow HPLC-Chip/MS systems at ISB in Seattle and at ETH Zurich.

"We believe this will be a revolutionary development in protein analysis," said Rob Moritz, ISB faculty member and director of Proteomics, "one that will accelerate and catalyze the routine use of protein quantitation for immensely important breakthroughs in the understanding, early detection and monitoring of human disease."

"Agilent is pleased to share leadership in creating the Human MRM Atlas and MRM-based methods to support quantitative protein research," said Ken Miller, Agilent director of LC/MS marketing. "The combination of our triple quadrupole instrumentation, software tools specific for protein analysis, and unique HPLC-Chip/MS technologies creates a stable, sensitive platform for the analysis of these large sample sets."

The MRM Atlas is designed to enable scientists to quantitatively access the approximately 20,000 proteins in human tissues, cell lines and blood, potentially transforming many areas of human health research. The project will produce a database of up to four peptides per human protein-coding gene, with verified rapid and accurate MRM-based mass spectrometric assays to enable the unambiguous identification and quantification of almost any protein in the human proteome. It is expected to benefit general biology research and large-scale proteomic studies.

About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is the world's premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis. The company's 18,000 employees serve customers in more than 110 countries. Agilent had net revenues of $5.8 billion in fiscal 2008. Information about Agilent is available on the Web at

About the Institute for Systems Biology

The Institute for Systems Biology (ISB) is an internationally renowned, non-profit research institute headquartered in Seattle and dedicated to the study and application of systems biology. Founded by Leroy Hood, Alan Aderem and Ruedi Aebersold, ISB seeks to unravel the mysteries of human biology and identify strategies for predicting and preventing diseases such as cancer, diabetes and AIDS. ISB's systems approach integrates biology, computation and technological development, enabling scientists to analyze all elements in a biological system rather than one gene or protein at a time. Founded in 2000, the Institute has grown to 14 faculty and more than 250 staff members; an annual budget of more than $35 million; and an extensive network of academic and industrial partners. For more information about ISB, visit

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Todd Langton, Institute for Systems Biology
+1 206 732 1200

Stuart Matlow, Agilent
+1 408 553 7191

Record changed: 2016-03-19


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