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Metabolon, Inc.. (8/3/09). "Press Release: New Research Offers Insight into Metabolomics Methods. Publication Details Technology for the Simultaneous Quantification and Qualification of Metabolites". Research Triangle Park, NC.

	Organisation	Metabolon Inc.
	Product	LC/MS (liquid chromatography/mass spectrometry)_other
	Product 2	GC/MS system

Metabolon, Inc., the leader in metabolomics-driven biomarker discovery and analysis, today announced the publication of a paper describing Metabolon's biochemical profiling technology. The paper, titled "Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems", appears in Analytical Chemistry.

"This paper describes a general method of profiling biochemicals in a high-throughput and scalable manner which enables the simultaneous quantification and identification of metabolites," explained Anne M. Evans, Ph.D., senior research scientist with Metabolon and lead author of the publication.

The system described in the paper is an integral part of Metabolon's commercial metabolomics platform. In addition to the UHPLC-MS/MS system, Metabolon employs a GC-MS system to provide additional breadth of coverage of biochemicals and metabolites.

Specific challenges associated with metabolomics analyses addressed in this paper include:

* Analytical platform variations and the specific advantages of a mass-spectrometry-based approach
* Discussion about the chemocentric approach to metabolite identification
* Challenges in identification and relative quantification of metabolites including elimination of experimental artifacts
* The large number of molecules able to be identified through this approach

Click here to read the complete abstract of the publication.

About Metabolon
Metabolon is a diagnostics and services company offering the industry's leading biochemical profiling platform. Metabolon's patented platform provides a global analysis of complex biological samples for the discovery of markers and pathways associated with drug action and disease. This metabolomics-driven approach enables the identification of biomarkers useful for the development of a wide range of diagnostics and provides insight into complex biochemical processes such as drug action, toxicology and bioprocess optimization. For more information about Metabolon, please visit www.metabolon.com.

Record changed: 2011-11-25

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