Waters Corporation. (6/3/05). "Press Release: New Technology for Advanced Proteomics and Biomarker Research. Expanded Feature Set for Waters nanoACQUITY UPLC TM System and New Nanoflow UPLC Capabilities for Biomolecule Applications". Milford, MA.

	Organisation	Waters Corporation (NYSE: WAT)
	Group	Waters (Group)
	Product	ACQUITY UPLC (Ultra Performance LC™) system
	Product 2	nanoACQUITY UPLC® system

Waters announced today it will introduce a new nanoflow chromatography system at ASMS, June 5 - 9, in San Antonio, TX. Waters® nanoACQUITY Ultra Performance LC System greatly enhances protein identification and characterization. Its new features increase the amount of information obtained from the most complex mixtures in proteomics applications.

The new suite of capabilities includes a unique direct nanoflow Ultra Performance LC approach, fully automated on-line two-dimensional liquid chromatography, a new fraction collector for LC/MALDI™ analysis and off-line two-dimensional LC applications. The Waters nanoACQUITY UPLC system now allows scientists to attain unparalleled analytical flexibility, sensitivity, reproducibility and resolution for protein identification and characterization.

Benefits of Ultra Performance LC Now Applied to NanoFlow Applications

Waters nanoACQUITY UPLC System is a first-of-its kind LC system designed to take full advantage of the chromatographic potential of novel sub two-micron particles at nanoscale flow rates to significantly enhance the resolution and peak capacity of a single chromatographic run, thereby providing more information per unit of time than any of today's nanoscale HPLC systems. To leverage the full potential of Waters' patented pressure-tolerant 1.7 mm reversed-phase particle technology, Waters' nanoACQUITY UPLC columns are now available in new lengths and capable of operating at pressures of up to 10,000 psi and at flow rates down to 200nl/min. to provide 2X the peak capacity of HPLC and unparalleled run-to-run reproducibility (<0.25 min relative standard deviation).

The combination of the nanoACQUITY UPLC with the enhanced speed, resolution and dynamic range of Waters Micromass ® Premier family of orthogonal time-of-flight (oa-Tof) mass spectrometers provide the highest LC/MS and MS/MS performance demanded of today's instruments for proteomics applications.

Adding Dimension to Protein Identification

A common approach for increasing the amount of information from complex proteomics samples is to reduce their complexity and dynamic range prior to mass spectrometry (MS) analysis by using two-dimensional liquid chromatography. To further improve the identification and increase the sequence coverage of high and low abundance proteins from complex samples, the Waters' nanoACQUITY UPLC system can now be configured for fully automated on-line 2D LC separations of complex protein digest samples using an ion exchange column in the first dimension, and reversed phase HPLC (nanoACQUITY columns with Atlantis ® chemistry) or UPLC (nanoACQUITY columns with BEH Technology™) in the second dimension. This easy-to-use system combines both high performance 2DLC and UPLC separations with minimal band broadening to vastly increase the information gained in the qualitative analysis of complex protein samples.

Maximizing Protein Identification by Combining UPLC, MALDI and Electrospray Ionization

For some of the most complex proteomics samples, many researchers choose to minimize sample complexity and dynamic range by first collecting discrete fractions from a gradient separation prior to MALDI or LC/ESI MS/MS analysis. In an agreement with CTC Analytics AG ( Zwingen, Switzerland), the CTC PAL™ microfraction collection platform will be sold with Waters nanoACQUITY UPLC system (utilizing HPLC and UPLC separations) for time-based fraction collection onto MALDI targets (96 or 384 format) or into 96-well or 384-well microtiter plates for LC/electrospray ionization (ESI) analysis. The popular CTC PAL MALDI Spotter/Fraction Collector is easy to use, minimizes band broadening to preserve high peak capacity nanoscale and capillary separations (using 300 m m to 75 m m ID columns), and is compatible with both HPLC and UPLC-based separations. By automating matrix addition to sample fractions, the CTC PAL MALDI Spotter/Fraction Collector can enable direct MALDI analysis and supports all MALDI target plates employed by the Micromass MALDI micro MX TM and new MALDI-enabled Q-Tof Premier TM Mass Spectrometer introduced at Pittcon 2005. The combination of the nanoACQUITY UPLC system and the flexible CTC PAL MALDI Spotter/Fraction Collector enables researchers to perform the best off-line nanoscale separations possible and, in combination with MALDI and electrospray mass spectrometry, complementary techniques that maximize the information content from every sample.

ASMS Presentations on nanoACQUITY UPLC Technology
The Waters nanoACQUITY UPLC system is described in a number of scientific posters at ASMS 2005. The following presentations will be available shortly after the conference at www.waters.com/posters:

– Design features and performance of a direct-flow nanoscale HPLC system combined with columns packed with sub two-micron particles
Jeffrey W. Finch, Martha D. Stapels, Keith Fadgen; Hongji Liu, Geoff Gerhardt, James C. Murphy, Steve Ciavarini, Christopher C. Benevides, John C. Gebler, Waters Corporation, Milford, MA
– A novel nanospray emitter design with a custom interface for nano-LC/MS, Ananya Dubey, James P. Murphy, Jeffrey W. Finch, John C. Gebler, Waters Corporation, Milford, MA

For more information on this instrument, scientists are asked to visit http://www.waters.com or contact their nearest Waters sales office.

About Waters Ultra Performance LC

Ultra Performance LC (UPLC) is a chromatographic separations technique first introduced at Pittcon 2004 with the Waters ACQUITY UPLC System. The ACQUITY UPLC systems are designed to take full advantage of the potential of novel sub two-micron particles to give scientists chromatographic run times that are up to 9X shorter than today's fastest HPLC systems, up to 2X better peak capacity or resolution, 3X better routine sensitivity and, generally speaking, more information from a single run than anything today's HPLC systems can provide.

Waters ACQUITY UPLC System was awarded a Pittcon Editors' Gold Award for Best New Product in 2004.

About Waters Corporation
Waters Corporation holds worldwide leading positions in three complementary analytical technologies - high performance liquid chromatography (HPLC), mass spectrometry (MS) and thermal analysis (TA). These markets account for $4.4 billion of the overall $20 + billion analytical instrumentation market.

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Waters, Micromass, ACQUITY Ultra Performance LC, nanoACQUITY Ultra Performance LC, ACQUITY UPLC, nanoACQUITY UPLC, Q-Tof Premier, Atlantis, Q-Tof, MALDI, MALDI micro MX and BEH Technology are trademarks of Waters Corporation. CTC PAL is a trademark of CTC Analytics AG.

Certain statements contained herein are forward looking. Many factors could cause actual results to differ from these statements, including delays in product introductions, loss of market share through competition, introduction of competing products by other companies, pressures on prices from competitors and/or customers, regulatory obstacles to new product introductions, lack of acceptance of new products, changes in the healthcare market and the pharmaceutical industry, changes in distribution of the Company's products, and foreign exchange fluctuations. Such factors are discussed in detail in the Company's filings with the Securities and Exchange Commission and, in particular, the Company's Annual Report on Form 10-K for the year ended December 31, 2004.

Record changed: 2011-11-25

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Waters Corporation. (6/3/05). "Press Release: New Technology for Advanced Proteomics and Biomarker Research. Expanded Feature Set for Waters nanoACQUITY UPLC TM System and New Nanoflow UPLC Capabilities for Biomolecule Applications". Milford, MA.

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