Advertisement

Highl Successful LC/MS Niche Player Is Looking for a Junior Partner 600x60px
Document › Details

Thermo Fisher Scientific Inc.. (2/15/12). "Press Release: Thermo Scientific Mass Spectrometers Drive Proteomics Breakthroughs Reported in Nature and Nature Methods". San José, CA.

Organisation Organisation Thermo Fisher Scientific Inc. (NYSE: TMO)
  Group Thermo Fisher (Group)
Products Product Orbitrap Elite hybrid orbitrap ion trap mass spectrometer
  Product 2 proteomics
Persons Person Jardine, Ian (Thermo Fisher 200803 VP Global Research + Develop)
  Person 2 Kubina, Stephanie (Thermo Fisher 201003)
     


Thermo Fisher Scientific Inc., the world leader in serving science, today announced that Thermo Scientific mass spectrometers continue to power breakthroughs in proteomics research as evidenced by recent publications in the prestigious journals Nature and Nature Methods. The unique capabilities of Thermo Scientific mass spectrometer systems played pivotal roles in 13 high-impact articles published in just over a month, from October 2 through November 6, 2011.

"The volume of preeminent articles using Thermo Scientific mass spectrometers published in a short timeframe highlights our leadership in providing technologies that address key challenges in proteomics," said Ian Jardine, chief technology officer, Analytical Instruments Group, Thermo Fisher Scientific. "For example, leading researchers are already taking advantage of the ultra-high resolution and speed of our new Thermo Scientific Orbitrap Elite hybrid mass spectrometer, to substantially increase the information obtained from top-down proteomics experiments."

In the articles, Thermo Scientific ion trap, triple quadrupole and Orbitrap-based mass spectrometers were used to advance important goals in proteomics: increasing the information produced by large-scale top-down proteomic studies, enhancing the quantitative accuracy of isobaric tagging methods, improving the productivity of glycoproteomics, and accelerating the pace of targeted quantitative discovery. Examples include:

Mapping intact protein isoforms in discovery mode using top-down proteomics is the most successful, large-scale top-down proteomic study published to date. The authors presented a four-dimensional approach in which the Orbitrap EliteTM and Thermo Scientific LTQ FT mass spectrometers were used to produce 20-fold increases in separating power and proteome coverage, on a liquid chromatography (LC) time scale.

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics presents a method to improve the accuracy and precision of quantitative data obtained from isobaric labeling experiments. The authors used the additional round of fragmentation (MS3) produced by the Thermo Scientific LTQ Orbitrap Velos mass spectrometer to reduce interferences from contaminating isobaric ions.

Gas-phase purification enables accurate, multiplexed proteome quantification with isobaric tagging also presented a method to reduce interferences and improved results when quantifying using isobaric labeling. The authors used the electron-transfer dissociation (ETD) on an LTQ Orbitrap VelosTM mass spectrometer to charge-reduce precursor ions. Once charge-reduced, the ions no longer exhibited overlapping m/z and thus no longer interfered with each other during quantification.

Nature is a weekly international journal publishing the finest peer-reviewed research. It is the world's most highly cited interdisciplinary science journal, according to the 2010 Journal Citation Reports Science Edition (Thomson Reuters, 2011). While most scientific journals are now highly specialized, Nature is among the few journals that still publish original research articles across a wide range of scientific fields.

For more information about Thermo Scientific mass spectrometry solutions, please call +1 800-532-4742, email analyze@thermofisher.com or visit www.thermoscientific.com/ms.


About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit www.thermofisher.com.

###

FOR IMMEDIATE RELEASE
Mass Spectrometry

Media Contact Information:
Name: Stephanie Kubina
Phone: +1 (408) 965-6022
Email: stephanie.kubina@thermofisher.com

   
Record changed: 2012-03-12

Advertisement

Banner Fairtec GmbH Worldwide Event Solutions 600x60px

More documents for Thermo Fisher (Group)


To subscribe to our free, monthly mass spectrometry newsletter, please send an e-mail to info@iito.de and simply fill the subject line with the word »MSC newsletter«

To get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]

Please visit also our web portals for the Eurpean life sciences and the life sciences in German-speaking Europe (DE, AT & CH) at Life-Sciences-Germany.com and Life-Sciences-Europe.com

Advertisement

Banner Fairtec GmbH We Optimise the ROI of Your Event 600x60px




» top

Advertisements

Highl Successful LC/MS Niche Player Is Looking for a Junior Partner 120x240px Banner EBD Group BIO Europe 2013 BEU Frankfurt November 120x120px Banner Dichrom GmbH Protea GPR 800 Protein Recovery System 120x120px Banner Vego Ltd Ecochem Conference 2014 Basel 120x120px Banner LSBC Central European Life Science Investment Conference 2014 120x180px Banner BIO Deutschland European Business Development Conference 120x240px The Events Group Pharm Connect Congress 2015 Budapest February 120x180px Banner Fairtec GmbH Solutions for Smarter Business Events Exhibitions 120x120px Banner [iito] Twitter iitoLifeScience Life Sciences Mass Spec 120x120px