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Shimadzu Scientific Instruments, Inc.. (5/10). "Press Release: New Products May 2010. MegaTOF Megadalton MALDI MALDI Mass Spectrometers".

Organisations Organisation Shimadzu Scientific Instruments Inc. (SSI)
  Group Shimadzu (Group)
  Organisation 2 CovalX AG
  Group CovalX (Group)
Products Product AXIMA™ mass spectrometer (product series)
  Product 2 mass spectrometry technology
  Index term 2 Shimadzu–CovalX: MegaTOF MALDI mass spectrometer, –201005 collab developm by integrating AXIMA MALDI system with HM2 high-mass system

Shimadzu and CovalX have partnered to offer an integrated MALDI solution for ultrahigh mass applications. The MegaTOF has been developed by optimizing the integration of a high-performance Shimadzu linear MALDI TOF mass spectrometer with a CovalX high-mass system, allowing outstanding detection of macromolecules up to 1500 kDa.
For these analyses, CovalX developed special cross-linking reagents and buffers for a fast and specific stabilization of protein interactions. The reagents contain 'cocktails' of cross-linkers with different spacer lengths able to covalently bind specific protein complexes with a high degree of efficiency. The specificity facilitates the stabilization of covalent protein complexes - even in contaminated or unpurified samples.


– High-sensitivity high-mass detector
o Detects macromolecules up to 1,500 kDa
– Conventional detector (electron multiplier)
o Ideally suited for low mass (<10 kDa) applications
– 15-second changeover time
– Stabilization of molecule using crosslinking reagent kits


– Antibody Characterization
o Antibody-Antigen interactions
o Epitope mapping
o Sandwich assays
– Therapeutic Protein Aggregates
– Inhibitors of Protein-Protein interactions
– Protein Complexes
– Characterization
– PEG Protein Characterization
– High-Mass MALDI Imaging
– Plasma Screening
– Polymer Analysis

Existing Shimadzu AXIMA MALDI systems (Assurance, Confidence, Performance) can be retrofitted with CovalX's HM2 or HM2 TUVO high-mass system.

Record changed: 2016-03-19


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