Thermo Fisher Scientific Inc.. (4/22/10). "Press Release: Thermo Fisher Scientific Collaborates on Clinical Biomarker Research with Leading Proteomics Researcher in Luxembourg".

	Region	Luxembourg
	Organisation	Thermo Fisher Scientific Inc. (NYSE: TMO)
	Group	Thermo Fisher (Group)
	Organisation 2	Luxembourg Clinical Proteomics (LCP) Unit (at CRP-Santé)
	Group	CRP-Santé (Public Research Center for Health Luxembourg)
	Product	mass spectrometry solution/method
	Product 2	LTQ Orbitrap Velos™ mass spectrometer
	Index term	Thermo Fisher–CRP-Santé: mass spectrometry methods, 201004– collab developm workflows clinical proteomics biomarkers + assays Prof Bruno Domon at LCP
	Index term 2	Thermo Fisher–ETH Zürich: mass spectrometry methods, 2007– collab developm proteomic biomarker approaches incl iSRM technology + Pinpoint s/w B Domon
	Person	Domon, Bruno (CRP-Santé 201004 Prof + Director LCP unit before ETZ Zurich Aebersold Group)
	Person 2	Jardine, Ian (Thermo Fisher 200803 VP Global Research + Develop)

Previous joint efforts led to development of original and exciting proteomics approaches for biomarker discovery and verification

Thermo Fisher Scientific Inc., the world leader in serving science, and Professor Bruno Domon, director of the new Luxembourg Clinical Proteomics unit (LCP), today announced a collaboration to develop workflows that overcome current bottlenecks in biomarker discovery and assay development for clinical proteomics research. The LCP is funded by the Fonds National de la Recherche (www.fnr.lu) and is hosted at Public Research Centre for Health (CRP-Santé).

Thermo Fisher has collaborated with Bruno Domon since 2007, and previous joint work has led to the development of original and exciting proteomics approaches for biomarker discovery and verification. Foremost among these is the cutting-edge intelligent Selected Reaction Monitoring (iSRM) technology now incorporated within the Thermo Scientific TSQ family of triple quadrupole mass spectrometers. iSRM reduces acquisition times for each peptide analyzed in a peptide biomarker panel, allowing both improved quantification and confirmation of the identity of the peptide being quantified. In addition to his part in developing iSRM, Bruno Domon was a primary scientific contributor to the Thermo Scientific Pinpoint software, which simplifies the creation of quantitative peptide assays on Thermo Scientific TSQ mass spectrometers and allows researchers to leverage knowledge acquired in previous qualitative proteomics discovery experiments.

Bruno Domon was recently appointed director of LCP initiative at CRP- Santé. He has established a biomarker research group that is active in clinical proteomics with a strong focus today on biomarker verification and plans to encompass metabolomics in the near future. The CRP-Santé research group will employ the recently introduced Thermo Scientific LTQ Orbitrap Velos hybrid mass spectrometer equipped with electron transfer dissociation (ETD) for biomarker discovery. This latest-generation hybrid linear ion trap-Orbitrap instrument is more accurate, faster and more sensitive than older generation LTQ Orbitrap instruments. It enables the massive, rapid and accurate identification of proteins in complex mixtures and the characterization of post-translational modifications. These capabilities are central to the creation of a second-generation biomarker discovery and validation workflow. In addition, the group will utilize the Thermo Scientific TSQ Vantage triple stage quadrupole mass spectrometer for fast, sensitive, accurate and reliable targeted protein quantification, and it will use Pinpoint software for rapid, automated assay development. The Thermo Scientific Exactive benchtop LC/MS mass spectrometer, which leverages proven Orbitrap™ technology, will be employed for biomarker profiling analyses.

"As a market leader in the development of tools for proteomics research, Thermo Fisher was the clear choice for collaborating on these clinical projects," said Bruno Domon. "By joining forces, I hope to build on our results to further develop workflows that will enable researchers to overcome challenges in biomarker discovery and verification."

"Bruno Domon is a leading researcher in proteomics, and his academic and industrial experience complements Thermo Fisher's commitment to producing proteomics solutions," said Ian Jardine, vice president of global R&D for Thermo Fisher Scientific. "This collaboration provides a unique opportunity for the company to expand its role in the development of cutting-edge biomarker research tools and consolidate its presence within the EU."

The newly established biomarker research group within CRP-Santé is part of a wider effort in Luxembourg to develop projects that are at the forefront of biomedical research. This effort includes the Integrated Biobank (IBBL) of Luxembourg, a state-of-the-art tissue storage and distribution initiative designed to help a worldwide network of cancer scientists and other disease researchers find answers to the world's most pressing health problems.

Overall, the Luxembourg government-led initiative, launched in 2008, is expected to support the development of cutting-edge skills and expertise in the field of molecular medicine. The objective is not only to strengthen the national research effort and benefit the country's healthcare system, but also to foster the diversification of Luxembourg's economic fabric in a promising and fast-growing sector. The research collaboration between Thermo Fisher Scientific and CRP-Santé substantiates this strategy and constitutes a first important milestone towards its implementation.

For more information on Thermo Scientific mass spectrometry solutions for biomarker research, please call 800-532-4752, email analyze@thermofisher.com or visit www.thermo.com/proteomics.

Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving science.

About CRP-Santé - Luxembourg Clinical Proteomics (LCP)

CRP-Santé employs 200 researchers and 50 support staff, working on some hundred research projects which resulted in 98 peer-reviewed publications in the year 2009. Its annual budget is currently around 35 million Euros, increasing each year.

CRP-Santé actively interacts with multiple international collaborations, the most relevant in the context of current proposal being the partnerships with TGen Foundation in Phoenix, Arizona (www.tgen.org) and with the Fred Hutchinson Cancer Research Center in Seattle, Washington (www.fhcrc.org).

CRP-Santé is a young research organisation with highly qualified personnel working in multidisciplinary teams with strong integration of laboratory, clinical and public health research. CRP-Santé's research focus is on health topics with high impact on the European population. The research units have state-of-the-art equipment in emerging fields of biomedical research and increasingly develop a market orientation aiming at commercial and clinical valorisation.

Luxembourg Clinical Proteomics (LCP) was created in December 2009 and has been funded by the Fonds National de la Recherche (FNR), with a start-up grant of 5 million Euros and a development plan for the next five years. A research group in is being recruited to launch the Luxembourg Clinical Proteomics Initiative in the next couple of months.

Bruno Domon, Head of the Luxembourg Clinical Proteomics Initiative (LCP) is relocating from ETH-Zurich (Prof. Ruedi Aebersold group) and has a wide scientific experience in academia: University of Lausanne, MIT Cambridge MA, University of Lille, France; and ETH Zurich) and in the private sector: Ciba/Novartis, Basel; Biogen, Cambridge MA; and Celera Genomics, Rockville MD.

For further information about CRP-Santé: www.crp-sante.lu.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of more than $10 billion, we have approximately 35,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit www.thermofisher.com.

Record changed: 2011-11-25

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Thermo Fisher Scientific Inc.. (4/22/10). "Press Release: Thermo Fisher Scientific Collaborates on Clinical Biomarker Research with Leading Proteomics Researcher in Luxembourg".

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