Thermo Fisher Scientific Inc.. (6/28/11). "Press Release: Thermo Fisher Scientific Collaboration with U.K. Health Protection Agency Yields Significant Development in Understanding Toxicity of the New E. coli Strain". Waltham, MA.

	Region	United Kingdom (GB)
	Organisation	Thermo Fisher (Group)
	Product	LTQ Orbitrap™ mass spectrometer
	Product 2	food analysis (food testing)
	Person	Jardine, Ian (Thermo Fisher 200803 VP Global Research + Develop)
	Person 2	O’Brien, Ron (Thermo Fisher 201003 Director Public Relations)

Mass Spectrometry Accelerates Research to Identify Microbiological Sources of E. coli-Related Illnesses and Disease

Thermo Fisher Scientific (NYSE: TMO), the world leader in serving science, today announced that its collaboration with the Health Protection Agency (HPA) in the U.K. has led to a significant development in mapping the proteome of the organism responsible for the recent E. coli outbreak in Europe. Using Thermo Scientific LTQ Orbitrap mass spectrometry technology, HPA researchers have identified the protein toxins expressed by the deadly strain, which has resulted in 37 deaths and made nearly 3,400 people ill.

The Health Protection Agency is an independent organization set up by the U.K. government in 2003 to protect the public from the threats of infectious diseases and environmental hazards. Thermo Fisher and the HPA are collaborating in a study on the use of mass spectrometry to better understand the role of microorganisms in causing illness and disease in humans.

"The significance of this study is that scientists were able to develop techniques to study microorganisms and determine how the genetic code is being translated into the protein building blocks that determine traits such as toxicity," said Dr. Ian Jardine, vice president, global research and development, Thermo Fisher Scientific. "Our leading Orbitrap(R) mass spectrometry system is providing researchers with the ability to understand what makes this E.coli strain so devastating, and may lead to an improved understanding of how to treat patients."

Orbitrap technology specifically enabled scientists to identify and analyze the protein fingerprint of this new strain of E. coli using a proteomic method that is rapid and reliable. Understanding the organism's ability to produce toxins and other proteins present in this specific strain may significantly reduce the risk to human health and provide more effective treatment options. This ability to identify toxic proteins and other proteins of significance in a disease process may also be applicable to a range of illnesses caused by microorganisms.

The HPA was assisted in its effort by representatives from Thermo Fisher's Hemel-Hempstead, U.K., facility. The full results of the research will be published in a future issue of a noted scientific publication.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit www.thermofisher.com.

Thermo Fisher Scientific

Media Contact:
Ron O'Brien, 781-622-1242
ron.obrien@thermofisher.com
www.thermofisher.com

or

Investor Contact:
Ken Apicerno, 781-622-1294
ken.apicerno@thermofisher.com

Record changed: 2011-11-25

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Thermo Fisher Scientific Inc.. (6/28/11). "Press Release: Thermo Fisher Scientific Collaboration with U.K. Health Protection Agency Yields Significant Development in Understanding Toxicity of the New E. coli Strain". Waltham, MA.

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