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Thermo Fisher Scientific Inc.. (6/16/14). "Press Release: Software Automates Deep Characterization of Biotherapeutic Proteins". Baltimore, MD.

Region Region Baltimore, MD
  Country United States (USA)
Organisations Organisation Thermo Fisher Scientific Inc. (NYSE: TMO)
  Group Thermo Fisher (Group)
  Organisation 2 Amgen Inc. (Nasdaq: AMGN)
  Group Amgen (Group)
Products Product PepFinder peptide mapping software
  Product 2 orbitrap mass spectrometer
Index term Index term Thermo Fisher–Amgen: mass spectrometry s/w, 201406 license existent to Mass Analyzer s/w as basis for Thermo’s PepFinder s/w
Persons Person Miller, Ken (Thermo Fisher 201111– VP Marketing Life Sciences MS before Agilent Marketing Director LC/MS)
  Person 2 Matlow, Stuart (Stu) (Thermo Fisher 201206 Public Relations Manager Chromatography + Mass Spectrometry before Agilent)
     


As protein-based drugs become more important in treating major diseases, producers face the critical challenge of deeply characterizing these highly complex molecules for efficacy and safety, as well as to meet quality requirements. A new software tool, Thermo Scientific PepFinder, is designed to increase the speed, quality and accuracy in comprehensive biotherapeutic protein characterization during drug development and production quality control.

PepFinder software is designed to streamline relative and absolute quantitation, and identification of proteins from biological samples using liquid chromatography-mass spectrometry (LC-MS). The new software is making its debut at the 62nd ASMS Conference on Mass Spectrometry and Allied Topics at the Holiday suite in the Hilton Baltimore Hotel.

Therapeutic proteins such as monoclonal antibodies, interferons and insulin must be produced in biologically active forms that have proper folding and specific post-translational modifications (PTM). Traditional analysis of these complex biological molecules is highly complex and time-consuming. PepFinder software uses multidimensional dynamic search capabilities to automatically integrate complex data into concise reports.

"This is a new paradigm for peptide mapping data analysis," said Ken Miller, vice president, marketing, life sciences mass spectrometry, Thermo Fisher Scientific. "Customers can expect to reduce analysis time from weeks to hours in some cases, while generating high-confidence, comprehensive characterization reports, including known and unknown modifications."

"Using PepFinder, a complex protein was analyzed with great details (including PTMs), and with great ease and speed," said Shiaw-Lin (Billy) Wu, head of analytical sciences, BioAnalytix and research associate professor at Northeastern University.

PepFinder software, based on Mass Analyzer software licensed from Amgen, is compatible with Thermo Scientific LC-MS instruments, including the industry-leading high resolution, accurate-mass Orbitrap-based systems. This software is designed for fast, high-quality PTM profiles and peptide identifications based on a novel prediction algorithm. The software displays sequence coverage maps, automates relative changes in site specific PTMs for rapid monitoring of modifications in a single sample or across sample comparison. The software is written to provide an automated workflow for glycopeptides ID, disulfide bond mapping and other common PTM's, including oxidation, deamidation and phosphorylation. This can eliminate time consuming and error-prone manual PTM mapping.

To learn more information about PepFinder, contact your Thermo Fisher Scientific representative today or visit us online at www.thermoscientific.com/pepfinder.


About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our four premier brands - Thermo Scientific, Life Technologies, Fisher Scientific and Unity Lab Services - we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermofisher.com.


###

Contact:

Stu Matlow
San Jose, Calif., USA
Phone: +1 408-965-6408
stu.matlow@thermofisher.com

   
Record changed: 2016-03-19

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