Thermo Fisher Scientific Inc.. (6/4/09). "Press Release: Thermo Fisher Scientific and NextGen Sciences Announce Collaboration. Under the Collaboration Arrangement, the BRIMS Center Will Work with NextGen Sciences to Apply New Technologies to NextGen Scie

	Organisation	Thermo Fisher Scientific Inc. (NYSE: TMO)
	Group	Thermo Fisher (Group)
	Product	biomarker discovery technology
	Product 2	LTQ Orbitrap XL™ mass spectrometer
	Person	Pisano, Mike (NextGen 200711– CEO)
	Person 2	Lopez, Mary F. (Thermo Fisher 2005– Director BRIMS before PerkinElmer before Proteome Systems before Genomic Solutions)

Thermo Fisher Scientific Inc., the world leader in serving science, today announced a collaboration between its Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center and NextGen Sciences, the biomarker specialists providing discovery, assay development and testing services. Under the collaboration arrangement, the BRIMS Center will work with NextGen Sciences to apply new technologies to NextGen Sciences' biomarkerexpress™ platform, a suite of biomarker services for developing, validating and applying targeted SRM assays for peptides and proteins in biofluids and tissues.

The collaboration will include providing NextGen Sciences with access to state-of-the-art Thermo Scientific mass spectrometry technology, which the company will add to its existing Thermo Scientific-based workflow. The biomarkerexpress™ workflow presently includes the following technologies and software for the biomarker discovery phase: Thermo Scientific LTQ Orbitrap XL mass spectrometer, Thermo Scientific SIEVE software for label-free differential analysis, and Thermo Scientific Proteome Discoverer software. The Thermo Scientific TSQ Quantum Ultra triple stage quadrupole mass spectrometer and Thermo Scientific Pinpoint software are employed for development and testing of panels of potential new biomarkers.

"We were diligent in our search for best-in-class instrumentation. While we were putting in place the infrastructure for our biomarker services it was important that we looked for reliable and accurate instruments, and Thermo Scientific technology was found to be just that," said Dr. Michael Pisano, CEO of NextGen Sciences. "In concert with our expertise at NextGen Sciences, Thermo Scientific technology delivers the highest quality results to our customers. The combination of Orbitrap™ technology and triple quad capability enables NextGen Sciences to go from discovery or named proteins to a single or multi-protein assay in a very short timeframe."

Ongoing Collaboration

NextGen Sciences has been working closely with BRIMS over the past year to develop an assay to verify osteoarthritis (OA) biomarker candidates in synovial fluid. The putative biomarkers were discovered in previous work performed at Harvard Medical School and Case Western Reserve University. The OA biomarker panel is currently being tested at NextGen Sciences on a 1,000-patient sample cohort provided by Harvard Medical School.

NextGen Sciences has already developed and continues to develop assays for verifying protein biomarker panels that can be implemented immediately on the Thermo Scientific TSQ Vantage triple stage quadrupole. These include: a 29-protein biomarker panel in cerebrospinal fluid (CSF) for Alzheimer's disease, a 20-protein biomarker panel in urine for prostate cancer, a 10-protein biomarker panel in plasma for colon cancer, a 10-protein biomarker panel in urine for pancreatic cancer, a Her2 biomarker panel in tissue, and the assay developed in collaboration with BRIMS for verifying the presence of OA biomarker candidates in synovial fluid.

"NextGen Sciences is carrying out very advanced work with respect to the development of assays targeting protein biomarker candidates in human matrices, such as CSF, plasma and tissue," said Dr. Mary Lopez, director of the BRIMS Center. "The company has the infrastructure and expertise necessary to develop and apply peptide assays in a commercial CRO setting in a reproducible and robust way. Above all, NextGen Sciences has a track record for delivering the highest quality data to the client, meeting short deadlines and providing excellent support through all stages of its research projects."

Developing Protein Biomarker Assays as a Service

Historically, immunoassays have been used to monitor levels of putative protein biomarkers in samples. While these assays provide high quality data, the development of multiplexed, quantitative protein assays has been a bottleneck in protein biomarker research for many years.

NextGen Sciences has broken this bottleneck by developing protein biomarker assays using mass spectrometry-based SRM (multiple reaction monitoring, also known as selected reaction monitoring). SRM has been used for over 20 years to monitor small molecule concentrations. In peptide SRM, proteotypic (unique) peptides from protein biomarker candidates are monitored. Availability of reproducible assays has been a major barrier for biomarker research and development. The biomarker assay development pipeline at NextGen Sciences is iterative and can handle large numbers of proteins, permitting investigators to empirically validate and select all of their biomarkers.

For more information about the TSQ Vantage™ triple stage quadrupole, TSQ Ultra™ triple stage quadrupole, Proteome Discoverer™ software, SIEVE™ 1.2 software, as well as other Thermo Scientific products, please call 1-800-532-4752, e-mail analyze@thermo.comor visit www.thermo.com/ms.

For more information on biomarkerexpress please call 1-734-730-7914, email info@nextgensciences.comor visit www.nextgensciences.com.
Thermo Scientific is part of Thermo Fisher Scientific, the world leader in serving science.

NextGen Sciences NextGen Sciences (AIM: NGG), the biomarker specialists, provide services to pharmaceutical and biotech companies globally. Using advanced techniques, such as Multiple Reaction Monitoring (MRM) mass spectrometry analysis, the Company is developing a portfolio of robust assays for testing clinical samples for drug safety and efficacy, and the development of personalized treatment for patients. NextGen Sciences' range of services, which include biomarker testing, discovery and assay development, are employed by its customers as a key part of the biomarker-based drug and diagnostic development process. For more information visit www.nextgensciences.com.

For NextGen Sciences
Lynne Trowbridge, Katie Odgaard, Benjamyn Tan +44 20 7457 2020
nextgen@collegehill.com

NextGen Sciences
Dr Michael Pisano, CEO
+1 734 973 7914

About Thermo Fisher Scientific Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, enabling our customers to make the world healthier, cleaner and safer. With 2008 revenues of $10.5 billion, we have approximately 34,000 employees and serve over 350,000 customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as environmental and industrial process control settings. Serving customers through two premier brands, Thermo Scientific and Fisher Scientific, we help solve analytical challenges from routine testing to complex research and discovery. The Thermo Scientific brand represents a complete range of high-end analytical instruments as well as laboratory equipment, software, services, consumables and reagents to enable integrated laboratory workflow solutions. Fisher Scientific provides a complete portfolio of laboratory equipment, chemicals, supplies and services used in healthcare, scientific research, safety and education. Together, we offer the most convenient purchasing options to customers and continuously advance our technologies to accelerate the pace of scientific discovery, enhance value for customers and fuel growth for shareholders and employees alike. Visit www.thermofisher.com.

Record changed: 2011-11-25

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Thermo Fisher Scientific Inc.. (6/4/09). "Press Release: Thermo Fisher Scientific and NextGen Sciences Announce Collaboration. Under the Collaboration Arrangement, the BRIMS Center Will Work with NextGen Sciences to Apply New Technologies to NextGen Scie

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