Advertisement

Picture BCNP Consultants European Chemistry Partnering 2018 Ffm Germany 600x60px
Document › Details

Vanderbilt University [Snyder, Bill]. (8/11/16). "Press Release: NIH Grant Bolsters Mass Spectrometry Research Initiatives".

Region Region United States (USA)
Organisations Organisation Vanderbilt University, Mass Spectrometry Research Center
  Group Vanderbilt University
  Organisation 2 NIH (US)
  Group United States (govt)
Products Product mass spectrometry imaging (MSI) (MALDI imaging)
  Product 2 mass spectrometry (MS)
Index term Index term Vanderbilt Univ–United States (govt): grant, 201607– renewal NIH grant $10.5m for 5 years to IMS Resource Research for imaging mass spectrometry
Person Person Caprioli, Richard (Vanderbilt Univ 200803 Prof Biochemistry + Director Mass Spectrometry Research Center)
     


The National Institutes of Health (NIH) has awarded a major renewal grant to continue the National Research Resource for Imaging Mass Spectrometry at Vanderbilt University School of Medicine.

The five-year, $10.5-million grant will support groundbreaking projects aimed at visualizing, at the molecular level, retinal disease, ovarian cancer, the impact of diabetes on the kidney and brain, and host-pathogen interactions in infectious diseases, said the grant’s principal investigator, Richard Caprioli, Ph.D.

Caprioli is the Stanford Moore Professor of Biochemistry and director of the Mass Spectrometry Research Center at Vanderbilt University Medical Center (VUMC), the site of the national resource.

In the late 1990s, his lab developed a technology called imaging mass spectrometry (IMS) to visualize the location of biomolecules in cells and tissues.

Essentially a “molecular microscope,” it measures the distribution, spatial rearrangement and alteration in expression levels of proteins, lipids and other biological molecules. IMS has particular relevance to cancer and has informed the study of human glioblastomas (brain tumors) as well as tumors of the breast, colon, prostate, skin and lung.

Last year, Caprioli’s team reported the first “image fusion” of mass spectrometry and microscopy, a technological tour de force that allows scientists to see the molecular make-up of tissues in high resolution.

Since it was established in 2011, the IMS Research Resource has supported projects leading to more than 50 scientific publications. It has produced instrumentation that can achieve a spatial resolution of 5 microns, about the size of a bacterium, and in special cases, down to 1 micron (1,000 nanometers).

The renewal grant will enable researchers to continue to push the boundaries of spatial resolution down to 500 nanometers — about the size of a virus, said Caprioli, who also is professor of Chemistry, Pharmacology and Medicine.

It also will support continued development of “image fusion” techniques pioneered at Vanderbilt “to produce images of uniquely high informational content not otherwise possible from any single modality alone,” he said.

The grant — P41GM103391 — was awarded earlier this summer by the National Institute of General Medical Sciences, part of the NIH. About $2.4 million was provided for the current fiscal year.


Media Inquiries:
Bill Snyder, (615) 322-4747
william.snyder@Vanderbilt.Edu

   
Record changed: 2016-09-08

Advertisement

Picture BIO Deutschland EBDC 2017 Heidelberg 600x60px

More documents for Vanderbilt University


To subscribe to our free, monthly mass spectrometry newsletter, please send an e-mail to info@iito.de and simply fill the subject line with the word »MSC newsletter«

To get even more information, please take a look at our [gs] professional services offering and read the gene-sensor Product Flyer [PDF file]

Please visit also our web portals for the Eurpean life sciences and the life sciences in German-speaking Europe (DE, AT & CH) at Life-Sciences-Germany.com and Life-Sciences-Europe.com

Advertisement

Picture EBD Group BioPharm America 2017 BPA Boston MA September 600x60px




» top

Advertisements

Picture [iito] Twitter iitoLifeScience Life Sciences Mass Spec 120x120px Picture BCNP Consultants European Chemistry Partnering 2018 Ffm 120x180px Picture BIO Deutschland EBDC 2017 Heidelberg 120x240px Picture EBD Group BioPharm America 2017 BPA Boston MA September 120x180px Picture [LSE] Life-Sciences-Europe.com – The Business Web Portal 120x600px Banner Fairtec GmbH Solutions for Smarter Business Events Exhibitions 120x120px Picture [iito] Twitter iitoLifeScience Life Sciences Mass Spec 120x120px Picture BIO Deutschland EBDC 2017 Heidelberg 120x240px Picture EBD Group BioPharm America 2017 BPA Boston MA September 120x180px Picture BCNP Consultants European Chemistry Partnering 2018 Ffm 120x180px