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HM2 high-mass system

	Next higher product group	mass spectrometry technology
	Status	2000-05-01 sales existent
	Organisation	CovalX AG
	Group	CovalX (Group)

Shimadzu Scientific Instruments, Inc.. (5/10). "Press Release: New Products May 2010. MegaTOF Megadalton MALDI MALDI Mass Spectrometers".

Shimadzu and CovalX have partnered to offer an integrated MALDI solution for ultrahigh mass applications. The MegaTOF has been developed by optimizing the integration of a high-performance Shimadzu linear MALDI TOF mass spectrometer with a CovalX high-mass system, allowing outstanding detection of macromolecules up to 1500 kDa.
For these analyses, CovalX developed special cross-linking reagents and buffers for a fast and specific stabilization of protein interactions. The reagents contain 'cocktails' of cross-linkers with different spacer lengths able to covalently bind specific protein complexes with a high degree of efficiency. The specificity facilitates the stabilization of covalent protein complexes - even in contaminated or unpurified samples.

Features

– High-sensitivity high-mass detector
o Detects macromolecules up to 1,500 kDa
– Conventional detector (electron multiplier)
o Ideally suited for low mass (<10 kDa) applications
– 15-second changeover time
– Stabilization of molecule using crosslinking reagent kits

Applications

– Antibody Characterization
o Antibody-Antigen interactions
o Epitope mapping
o Sandwich assays
– Therapeutic Protein Aggregates
– Inhibitors of Protein-Protein interactions
– Protein Complexes
– Characterization
– PEG Protein Characterization
– High-Mass MALDI Imaging
– Plasma Screening
– Polymer Analysis

Existing Shimadzu AXIMA MALDI systems (Assurance, Confidence, Performance) can be retrofitted with CovalX's HM2 or HM2 TUVO high-mass system.

Record changed: 2011-11-25

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HM2 high-mass system

Shimadzu Scientific Instruments, Inc.. (5/10). "Press Release: New Products May 2010. MegaTOF Megadalton MALDI MALDI Mass Spectrometers".

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