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AXIMA MegaTOF™ MALDI Mass Spectrometer

	Next higher product group	MALDI-TOF mass spectrometer
	Status	2010-05-23 sales start
	Organisation	Shimadzu (Group)
	Organisation 2	CovalX AG
	Group	CovalX (Group)

Shimadzu Scientific Instruments, Inc.. (6/2/10). "Press Release: Shimadzu and CovalX Launch the AXIMA MegaTOF for Ultrahigh-mass Applications".

Shimadzu Scientific Instruments has partnered with CovalX to offer the AXIMA MegaTOF™, an integrated MALDI solution for ultra high-mass applications, including protein complex characterization, therapeutic protein aggregates, antibody-antigen interactions, polymer analysis and high mass bioimaging.

The high-sensitivity MegaTOF, which combines a high-performance Shimadzu linear MALDI TOF mass spectrometer with a CovalX high-mass detection system, detects macromolecules up to 1,500 kDa. When analyzing intact protein complexes by high-mass MALDI TOF, it is crucial to stabilize the complexes with highly efficient cross-linking reagents. The MegaTOF achieves this with the combination of CovalX's high-mass system offering nM detection of macromolecules up to 1500 kDa and MALDI stabilization kits, which provide special cross-linking reagents and buffers for a fast and specific stabilization of protein interactions.

These reagents contain "cocktails" of cross-linkers with different spacer lengths that can covalently bind specific proteins with a high degree of efficiency, even in contaminated and unpurified samples. Additionally, the MegaTOF can detect protein interactions such as aggregation directly from formulation mixtures, which is important for characterizing biopharmaceuticals.

MegaTOF is also equipped with a conventional detector for low mass samples (<20 kDa). In addition, existing Shimadzu AXIMA MALDI systems (Assurance, Confidence, Performance) can be retrofitted with CovalX's HM2 or HM2 TUVO high-mass system.
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If you should need more information, or have any questions, you may contact our Press Department:
Phone Number: 1-800-477-1227 / Email: kgmclaughlin@shimadzu.com

Record changed: 2011-11-25

More documents for MALDI-TOF mass spectrometer

• [1] Bruker Corporation. (3/31/12). "Press Release: Bruker Expands MALDI Biotyper Capabilities with New Protocols and Reference Libraries for Myobacteria and Multicellilar Fungi". London....
• [2] Bruker Corporation. (3/31/12). "Press Release: Bruker and University Medical Center Groningen (UMCG) Announce a Collaboration within New European Network for Rapid Identification of Anaerobes (ENRIA)". London....
• [3] Bruker Corporation. (3/6/12). "Press Release: Bruker High-field NMR and Mass Spectrometry Instrumentation at the National Polytechnic Institute of Mexico City Will Promote Nanoscience Research in Mexico". Mexico City....
• [4] University of Bremen. (1/29/12). Web Site. MALDI Imaging Core Facility. [http://www.uni-bremen.de, 02/14/12]...
• [5] Bruker Corporation. (1/27/12). "Press Release: Bruker and Siscapa Assay Technologies Announce Joint Publication on SISCAPA-MALDI-TOF Mass Spectrometry for Biomarker Validation and Clinical Research". Billerica, MA....
• [6] Bonislawski, Adam. (12/23/11). "News: UCSF Researchers ID Peptides that May Dramatically Boost HIV Infection Rates"....
• [7] Quotient Bioresearch Ltd.. (9/19/11). "Press Release: Quotient Bioresearch Announces First Use of Bruker MALDI Biotyper for Bacterial Identification"....
• [8] Salk Institute. (7/31/11). Web Site. Mass Spectrometry Core Facility (The Vincent J. Coates Foundation Mass Spectromery Center). [http://www.salk.edu, 07/31/11]...
• [9] Bruker Corporation. (6/27/11). "Press Release: Laboratory Viollier Extends the Business Relationship with Bruker Concerning MALDI Biotyper System for Mass Spectrometry-based Microbial Identification". Geneva....
• [10] Bruker Corporation. (6/27/11). "Press Release: Bruker and the Institute of Medical Microbiology at the University of Zurich Announce a Collaboration for Mass Spectrometry-based Microbial Identification". Geneva....

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