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Collaboration › Details

Freenome–Biognosys: proteomic technology, 201804– collab enhancing circulating NA cancer test with proteomics data


Period Period 2018-04-24
Organisation Partner, 1st Biognosys AG
  Group Bruker (Group)
Products Product proteomic technology
  Product 2 cancer test, early detection

Freenome, Inc.. (4/24/18). "Press Release: Freenome and Biognosys Announce Collaboration to Improve Early-Cancer Detection and Treatment". South San Francisco, CA & Zurich.

AI genomics company Freenome today announces its partnership with leading proteomics company Biognosys to enhance its broad-signal approach to early-cancer detection and precision oncology. By decoding cell-free (cf) biomarker patterns of once unthinkable complexity, Freenome’s artificial intelligence (AI) genomics platform is poised to detect cancer at its earliest stages and help clinicians optimize the next generation of precision therapies.

At the molecular level, the existence of circulating fragments of tumor DNA (ctDNA) in the blood is well established; however due to statistical, biologic, and economic limitations, ctDNA has been shown to be an unreliable stand-alone biomarker for early-cancer screening.

Freenome’s AI genomics platform looks beyond tumor DNA to analyze the body’s own response to cancer – the fragments of cfDNA and cfRNA that are released into the bloodstream when the presence of cancer leads to the destruction of immune and other cells in the tumor environment. Partnering with Biognosys enhances Freenome’s multi-analyte, broad-signal approach by adding protein quantification of exceptional depth and precision in the development of its first commercially available screening test.

“We are pleased to work with Freenome, which is committed to going beyond the traditional single-analyte approach to genomic diagnostics,” said Oliver Rinner, PhD, CEO of Biognosys. “Its AI genomics platform is a natural fit for our next-generation proteomics technology, which supplies unbiased quantitative information about hundreds of proteins and thousands of peptides from a single sample analysis.”

According to Imran Haque, PhD, Chief Scientific Officer at Freenome, “Changes in protein expression can be either direct or surrogate markers for emerging disease processes in the body. Working with Biognosys gives us a distinct and complementary type of information to use alongside our genomic sequencing data, which in turn may improve the performance of our tests.”

In addition to its promise in early cancer screening, Freenome’s AI genomics platform has attracted academic institutions and Fortune 500 pharmaceutical companies interested in solving other pressing challenges in cancer and other diseases, from predicting drug response to revealing novel targets for the next-generation of immuno-oncology and targeted therapies.

About Freenome

Freenome is an AI genomics company on a mission to empower everyone with the tools they need to detect, treat, and ultimately prevent their diseases. By applying advanced machine learning techniques to recent breakthroughs in genomic science, Freenome is developing noninvasive blood tests to detect early-stage cancer and make treatments more effective. The company has raised $78 million from investors such as Andreessen Horowitz, Google Ventures, Polaris Partners, and Founders Fund. More information at:

About Biognosys

Biognosys is a leader in next-generation proteomics, dedicated to transforming life science research by making the most advanced proteomics tools available to researchers. The company offers a suite of products and services to decode the proteome and equip researchers from all fields with a deep view of protein expression in cells, tissues, or body fluids. Biognosys’ technology is based on high-resolution mass spectrometry, combined with a novel parallel signal processing approach, for unprecedented quantification of large proteomes in a single experiment. More information at:


Lena Cheng, MD, 650-822-7962


Nicholas Dupuis, PhD, 646-281-3645

Record changed: 2021-11-16


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