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Biognosys AG. (4/4/14). "Press Release: Biognosys’ Spectronaut Software Now Supports Spectral Library Generation". Zurich-Schlieren.

Organisations Organisation Biognosys AG
  Organisation 2 Thermo Fisher Scientific (Bremen) GmbH
  Group Thermo Fisher (Group)
Products Product Spectronaut™ data analysis s/w for SWATH and HRM-MS data
  Product 2 HRM-MS technology (Hyper Reaction Monitoring)
Person Person Aebersold, Ruedi (ETH Zurich 2005c– Professor Systems Biology before Institute of Systems Biology Seattle)

The new Spectronaut™ software release offers a comprehensive solution for proteome quantification

Biognosys AG, a Swiss Proteomics Company, announced today the third release of its Spectronaut™ software for analysis of Hyper Reaction Monitoring (HRM) data. HRM-MSTM is a targeted proteomics technology developed by Biognosys that enables reproducible and accurate quantification of 1000s of proteins in a single instrument run. It combines the shotgun proteomics' ability to identify large sets of proteins and the quantitation accuracy of MRM/SRM.

HRM is based on data-independent acquisition (DIA) performed on the new generation mass spectrometric systems like the Thermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap mass spectrometer or AB SCIEX TripleTOF® 5600+ System. HRM combines DIA with high resolution MS/MS, large spectral libraries and a targeted approach for data deconvolution and analysis. Spectronaut™ now also supports the generation of spectral libraries, which has been a bottleneck until now.

The Spectronaut™ software was first launched by Biognosys in January 2013 for analysis of SWATH data and updated in August 2013 when support of DIA data generated on the Q Exactive was introduced. With the current release Biognosys provides the most straightforward solution for proteome quantification currently available on the market.

Other new features of this Spectronaut™ release include a quality control perspective (based on the HRM Kit peptides), interference scoring, fragment ion reporting, and many more. The detailed information on Spectronaut™ and its features can be found in the software manual.

The powerful principle behind Spectronaut™ is the integration of the software algorithms with a reagent kit - HRM Calibration Kit - that provides optimal customized parameter calibration that is crucial for quantitation accuracy and reproducibility.

With the third Spectronaut™ release that is free for academic researchers Biognosys unleashes the full capability of the HRM-MSTM technology, which is also available at Biognosys as a service for discovery applications.

About Biognosys

Biognosys is the leading proteomics company offering services and products for highly multiplexed protein quantification. Founded in 2008 as spin-off from the lab of proteomics pioneer Ruedi Aebersold at ETH Zurich, Biognosys is dedicated to transform life science with superior technology and software.


Record changed: 2016-03-20


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