Lipotype GmbH. (10/8/18). "Press Release: Skin Lipidomics in Cosmetics and Dermatology. Lipotype Provides Royal DSM and Lipoid with Shotgun Skin Lipidomics". Dresden.

	Organisation	Lipotype GmbH
	Product	mass spectrometry services (MS services)
	Product 2	cosmetics
	Index term	DSM–Lipotype: mass spectrometry services, 201810 collab supply of shotgun skin lipidomics services by Lipotype to Royal DSM
	Index term 2	Lipoid–Lipotype: mass spectrometry services, 201810 collab supply of shotgun skin lipidomics services by Lipotype to Lipoid GmbH
	Person	Deda, Henri (Lipotype 201802– Marketing Assistant)

The physiology of skin derives from its structure and composition of its topmost layer, where cells are glued together by lipids. Their composition is influenced by natural conditions, such as age and gender, but also various diseases. Lipotype provided Royal DSM and Lipoid with lipid analysis to investigate the human skin.

The mass spectrometry-based Lipotype Shotgun Skin Lipidomics technology provides the tools to investigate how the healthy skin lipidome is composed, how it changes in diseases or upon intervention with a drug or a cosmetic product. This lipidomic data can be used for cosmetic claim support, topical drug development and personalized cosmetics.

Royal DSM – photodamaged dry facial skin from different ethnic groups

Even though decades of moisturizer development have passed, dry facial skin remains a major concern for consumers. Thus, DSM’s aim was to understand more precisely the underlying biochemistry, particularly of the maturation of the stratum corneum and its relation to facial photodamage, skin pigmentation and ethnicity. In contrast to traditional research of skin analyte composition, a more revolutionary ‘omic’ approach was applied.

Lipotype delivered lipid analysis of the ceramidome, the entirety of ceramides. The results precisely highlight changes in ceramide composition and distribution which help to explain the differences in facial skin barrier function, hydration and stratum corneum maturation, but also the skin care need of the differently pigmented skin types.

The full customer reference can be downloaded through Lipotype’s website as well as additional material like white papers and similar case studies

Lipoid – skin penetration properties of saturated phospholipids

Lipoid conducted this novel study to investigate skin penetration properties of dermal formulations based on hydrogenated phospholipids. Common to all topically used phospholipids is their ability to interact with skin structures and the similarity to epidermal lipids.

For the first time, the quantitative analysis of both exogenous phospholipids and endogenous skin lipids within a single measurement was demonstrated. The results confirm the properties of hydrogenated phospholipids to penetrate and accumulate in upper epidermal layers.

Lipotype performed lipid analysis of phospholipids of an applied formulation, especially focusing on phosphatidylcholine. Based on these findings, Lipoid will conduct further investigations to improve delivery and fixation of an active pharmaceutical ingredient.

The full customer reference is accessible through Lipotype’s website as well as complimentary material on this research project.

Media Contact:

Henri Deda
T: +49 (0) 351 79653-45
deda@lipotype.com
Lipotype GmbH
Tatzberg 47, 01307 Dresden
Germany
www.lipotype.com

About Lipotype

Lipotype delivers comprehensive, absolutely quantitative lipid analysis services for clinical and biological samples on a high-throughput scale. Drawing on many years of cutting edge research experience, Lipotype offers high quality lipid analysis services for a wide range of customers and applications including biomarker identification for clinical researchers, pharma and biotech companies, functional food development for the food industry, claim support for the cosmetics industry, as well as for the small-scale profiling needs of academic researchers.

Lipotype is a spin-off company from the Kai Simons and Andrej Shevchenko labs of the world-renowned Max-Planck-Institute of Molecular Cell Biology and Genetics in Dresden, Germany.

About Royal DSM

Royal DSM is a purpose-led global science-based company in Nutrition, Health and Sustainable Living. With its innovative business solutions for human nutrition, animal nutrition, personal care and aroma, medical devices, green products and applications, DSM is driving economic prosperity, environmental progress and social advances to create sustainable value. DSM’s purpose is to create brighter lives for people today and generations to come.

About Lipoid

Phospholipids are widespread functional ingredients, not only in pharmaceutical formulations, but in cosmetic and dietetic products as well. Lipoid was the first to offer a wide variety of phospholipids for use in the production of drug products. Today, the majority of approved drugs containing phospholipids are prepared using raw materials from Lipoid.

Record changed: 2023-06-05