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Shimadzu Corporation. (9/1/10). "Press Release: Shimadzu Introduces World Fastest Tandem Quadrupole LC/MS/MS System. Provides Speed Beyond Comparison for Multi-analyte Determination".

Region Region Japan
Organisation Organisation Shimadzu Corporation
  Group Shimadzu (Group)
Products Product LCMS-8030 triple quadrupole mass spectrometer (Shimadzu)
  Product 2 Nexera UHPLC system

Shimadzu Corporation announces the ultra-fast triple quadrupole LC-MS system, the model LCMS-8030, and user-friendly LabSolutions LCMS workstation software. With its exceptionally fast electronics and robust design, the LCMS-8030 is ideally suited for analysis of a wide range of applications, such as detection of drugs and metabolites from large numbers of biological specimens, contaminants from environmental samples or pesticides in food for high-throughput laboratories.

Shimadzu's LCMS-8030 features the most innovative technology ever put into a commercial tandem quadrupole analyzer. The new instrument includes an ultra-fast pulse counting detection system, an innovative high-speed UFsweeperTM collision cell, and a novel RF power supply that can switch conditions and achieve complete stability in microseconds. These innovations allow this tandem quadrupole mass analyzer to provide the fastest measurements possible, including a scan speed of up to 15,000 u/sec without any compromise of resolution, sensitivity or mass range. With reproducible MRM results with just one millisecond dwell times, the LCMS-8030 can perform up to 500 different MRM measurements per second. With the current trend going toward higher pressure HPLC and faster operating speeds for greater throughput, the LCMS-8030 is the ideal detector to keep up with the ever faster chromatographic peaks. Fast 50 millisecond UHPLC peaks are now easily tamed by the LCMS-8030.

*A triple quadrupole liquid chromatograph mass spectrometer (LC-MS) is a three-stage mass analyzer in which molecules in the form of ions are first selected by mass, fragmented in a collision cell, and then measured and quantitated in a separate quadrupole analyzer. This type of instrument provides extremely high selectivity of target constituents, provides quantitation at ultra-low levels, and can be used in wide-ranging fields from pharmaceuticals and life sciences to leading-edge materials research, foods, and environmental analysis.

Development Background

In recent years, interest in health and safety has grown significantly, and the list of regulated compounds and analytes has increased as well. For food safety, Japan implemented a "positive list" in 2006 which includes over 700 compounds that have to be measured and reported, and certifying safety is now a requirement for both importing and exporting countries. The demand for multi-compound and multi-analyte analysis continues to grow, even in emerging countries that mainly export agricultural products. In Japan, strengthening regulations for industrial use of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), additives and residual pharmaceutical and personal care products (PPCP) in the environment is progressing, which in turn is creating demand for instrumentation that provides reliable trace-level determination. In addition, pharmaceutical companies are under more pressure to speed up development of new drugs. Their demand for high-throughput analysis to test pharmacokinetics of possible drug candidates in clinical trials or providing faster quantitative results to support new development efforts is growing.

Shimadzu Corporation is responding to market demand for fast and high-sensitivity analysis of trace-level and multi-analyte analysis by continually expanding our product line. Our recently released Nexera UHPLC features a world-class pressure range up to 130MPa (19000 psi), shortening analysis times and tripling the separation capacity, compared to typical 40 MPa (6000 psi) instruments. In order to instantly capture and ionize the samples separated by ultrafast LC and to obtain appropriate quantification data, speeding up the LC-MS is a necessity. Shimadzu Corporation answered this need in 2008 with the release of the world's fastest single quad LCMS-2020, and now builds on that speed by introducing the incomparable LCMS-8030.

Now, the LCMS-8030 will maximize the world-class performance of Nexera and provide the solution to the growing high-speed and trace-level analysis markets.

Unique Product Features

1) Ultra high-speed performance enables the world-class data acquisition speed and high reliability

A unique technology created by Shimadzu with the LCMS-8030 enables world-class ultra high-speed measurement and reproducibility. In triple quadrupole LC/MS analysis, a collision gas is used to bring about collision induced dissociation (CID*) of ions in the cell. However, re-accelerating ions to the mass analyzer after collision has been a slow part of the operation. The "CID cell", at the heart of the triple quadrupole LC-MS, incorporates Shimadzu's innovative tapered "octaplate" UFsweeperTM cell technology (patent pending) that allows faster and more stable measurements than ever.

The UFsweeper collision cell prevents cross-talk from accumulated ions from affecting the measurement of the next compound, ensuring highly stable and reliable data. For comparison purposes, the Shimadzu LCMS-8030 improves Relative Standard Deviation (RSD) values by a factor of two over currently available instruments.

(*) Collision induced dissociation (CID) -fragments ionized compounds selected by the mass analyzer for further analysis.

The LCMS-8030 provides ultra-fast MRM transitions, enabling data acquisition with up to 500 different channels per second. The improvements to the electronics provide ultra fast scan mass spectrum measurement speeds of 15,000 u/sec without sacrificing sensitivity or resolution, and ultra-fast polarity switching (15msec) for the most information without signal deterioration.

These features result in superior reproducibility for detection of peaks only one second wide or less. For example, the LCMS-8030 can elute 226 pesticides included in the positive list within 2 minutes and easily provide reliable and accurate quantitative results.

2) User-friendly operation and maintenance

Unified software for LC and LC-MS

Software is a critical component with respect to analytical instrumentation. The LCMS-8030 software was designed to provide intuitive, easy-to-use operation. It fully integrates operation of Shimadzu's LC product lines (Nexera, Prominence) and LCMS-2020 single quadrupole LC-MS. Automated optimization of analytical conditions for each quantitative target compound, which is the key to high-sensitivity analysis, allows unattended, overnight operation, greatly lessening the burden on users. Finally, its multilingual support includes Japanese, English and (soon to come) Chinese.

Automated optimization of analysis conditions

The unified presentation of instrument parameters and displays
was specifically designed to enhance user-friendly operation.

Minimize instrument downtime with Easy Maintenance

The desolvation capillary through which ions are guided into the MS can be quickly replaced without breaking vacuum, a process that otherwise requires spending a day conducting maintenance. In addition, switching between multiple ion sources is a quick, tool-free operation. These are some of the highly-valued features of the LCMS-2020 which have been incorporated into the LCMS-8030 to provide users with easier operation and maintenance.

Shimadzu has the highest market share in our domestic market for applications such as R&D and impurity analysis in pharmaceuticals and chemical synthesis for single quadrupole LC-MS. We expect to engage with the newly developed LCMS-8030 into the triple quadrupole market.

Record changed: 2019-06-09


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