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Siscapa Assay Technologies, Inc.. (7/12/17). "Press Release: Siscapa Licenses Liquid Chromatography/Mass Spectrometry Assay Technology to Waters Corporation". Washington, DC.

Organisations Organisation Siscapa Assay Technologies Inc. (SAT)
  Organisation 2 Waters Corporation (NYSE: WAT)
  Group Waters (Group)
Products Product SISCAPA® assay (Stable Isotope Standards and Capture by Anti-Peptide Antibodies)
  Product 2 LC/MS (liquid chromatography/mass spectrometry)
Index term Index term Waters–Siscapa: mass spectrometry, 201707– license non-excl to certain SAT technology for standardisation of liquid LC/MS assays
Persons Person Anderson, N. Leigh (Plasma Proteome Institute 200808 + SCISCAPA Assay Technologies)
  Person 2 Mazzeo, Jeffrey R. (Jeff) (Scitara 202206– Chief Marketing Officer before Waters)

SISCAPA Assay Technologies, Inc. (SAT), developer of precision mass spectrometry assays for protein quantitation, today announced that Waters Corporation has obtained a nonexclusive license to certain technology from SAT for the standardization of liquid chromatography/mass spectrometry assays.

The patent-pending technology uses multiple stable isotope-labeled versions of an analyte molecule, each with a distinct mass increment, added to a sample at different known concentrations as a way to establish a within-sample internal standard curve. Such a multi-point internal standard curve offers operational advantages such as speed of analysis and a reduction in cost and time to results as compared to external calibration (in which a set of calibrators must be run before a test sample), or internal calibration using a single stable-isotope labeled standard (“single-point” calibration).

“We are extremely happy to enable Waters’ use of this technology, which is applicable to proteins, peptides and small molecules,” said Leigh Anderson, SAT’s CEO. “The approach could be particularly valuable in bringing mass spectrometry assays into the clinical laboratory, where calibration using a standard curve is established practice. Importantly, this approach fits well with our SISCAPA protein assay panels used to measure protein biomarkers in serum and dried blood microsamples.”

Dr. Jeff Mazzeo, V.P. of Marketing, Waters Corporation, commented: “With the licensing of SAT’s technology, we are now in the process of evaluating the benefits of the approach for quantitative LC/MS assays in a number of application areas.”

About SISCAPA Assay Technologies, Inc. (

SISCAPA Assay Technologies Inc. (SAT) delivers tools for development of high-sensitivity, high-throughput specific assays for proteins, including clinical biomarkers, using SISCAPA® (Stable Isotope Standards and Capture by Anti-Peptide Antibodies) technology.

About Waters Corporation (

Waters Corporation (NYSE: WAT), the world's leading specialty measurement company, has pioneered chromatography, mass spectrometry and thermal analysis innovations serving the life, materials and food sciences for nearly 60 years. With approximately 7,000 employees worldwide, Waters operates directly in 31 countries, including 15 manufacturing facilities, and with products available in more than 100 countries.

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SISCAPA is a registered trademark of SISCAPA Assay Technologies Inc. in the United States and/or other countries.

Waters is a registered trademark of Waters Corporation.

Contact: Leigh Anderson at 301-728-1451

Record changed: 2023-06-05


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