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Thermo Fisher Scientific Inc.. (2/8/11). "Press Release: Collaboration Announced with Harvard’s Massachusetts General Hospital in Stroke Research". San José, CA.

Region Region United States (USA)
Organisations Organisation BRIMS Center (Thermo Fisher)
  Group Thermo Fisher (Group)
  Organisation 2 Massachusetts General Hospital (MGH)
  Group Partners HealthCare System (Group)
Products Product mass spectrometry (MS)
  Product 2 MSACL 2011 US San Diego
Person Person Lopez, Mary F. (Nuclea Biotechnologies 201502– COO before Thermo Fisher BRIMS + PerkinElmer + Proteome Systems)

Thermo Fisher Scientific Inc., the world leader in serving science, today announced the initial findings of stroke research conducted by its Biomarker Research Initiatives in Mass Spectrometry (BRIMS) Center in collaboration with Massachusetts General Hospital (MGH), Harvard University. Strokes are the leading cause of serious long-term disability in the U.S. The research, conducted using Thermo Scientific mass spectrometers, provides insight into key areas of stroke evaluation and treatment. The research will be previewed at the MSACL conference in San Diego in February, 2011.

Led by Dr. MingMing Ning, a clinical neurologist and researcher at the Clinical Proteomics Research Center at MGH, the research provides potentially significant new insight into patent foramen ovale (PFO) and its connection with strokes. PFO refers to a congenital heart abnormality which leaves open a passage between the left and right sides of the heart, enabling blood clots to travel from the leg to the brain. With PFO affecting 25 percent of the worldwide population, the potential health impacts are significant. Identification of potential biomarkers in mass spec data derived from the collaborative research provides scientists with new insights into how PFO can be related to strokes. If confirmed, these insights may be important in helping doctors to select the most appropriate treatment for individual PFO stroke patients.

The collaboration between the BRIMS Center and Harvard University has also led to potential insights in the understanding of tissue plasminogen activator (tPA) in stroke treatment. tPA is a drug that can be safely administered only within a very short time window after stroke symptoms occur. The treatment, which works by dissolving blood clots, has proven highly effective but involves significant risks. Only 5 percent of patients fit the timeframe criteria within which it is safe to administer tPA. Through the use of mass spectrometry-based proteomics workflows, data from the collaborative research may someday help scientists identify a wider scope of patients who might benefit from tPA.

Dr Ning comments: "We are now able to conduct research directly at the beside of acute stroke patients, thanks to the collaboration between Dr. Mary Lopez and her team at the BRIMS Center; Dr. Tom Jacobs at NIH/NINDS; and Dr. Eng H Lo, Dr. Ferdinando Buonanno and Dr. Anne Young at the Clinical Proteomics Research Center at MGH. This was not possible before and has allowed us to build a crucial bridge from research to treatment, enabling us to gather key research information in real-time."

For more information about Thermo Scientific solutions for proteomic research, please call +1 800-532-4742, email or visit

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of nearly $11 billion, we have approximately 37,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through two premier brands, Thermo Scientific and Fisher Scientific, which offer a unique combination of continuous technology development and the most convenient purchasing options. Our products and services help accelerate the pace of scientific discovery, and solve analytical challenges ranging from complex research to routine testing to field applications. Visit

Record changed: 2016-03-19


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