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Thermo Fisher Scientific Inc.. (3/9/15). "Press Release: Transformative UHPLC System Showcases Performance and Throughput". New Orleans, LA.

Region Region New Orleans, LA
  Country United States (USA)
Organisations Organisation Thermo Fisher Scientific Inc. (NYSE: TMO)
  Group Thermo Fisher (Group)
  Organisation 2 Pittcon (The Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy Inc.)
Products Product Vanquish UHPLC system
  Product 2 Pittcon 2015 New Orleans
Persons Person McLeod, Fraser (Danaher 201705– VP + General Manager Software Business at Sciex before Thermo Fisher)
  Person 2 Hudson, Kena (Chempetitive 201503)

New Design Combines Flexibility of Modular Stacks with Robustness of Integrated Systems

A new ultra high-performance liquid chromatography (UHPLC) system has been designed for enhanced levels of performance, productivity and usability for laboratories performing life science research and other demanding analyses.

The new Thermo Scientific Vanquish UHPLC, exhibited for the first time at Pittcon 2015 (booth 2523) at the Ernest N. Morial Convention Center, New Orleans, features a clean design that combines the ruggedness of an integrated system with the flexibility and serviceability of a modular system. The Vanquish system can be used as a standalone system or with the latest mass spectrometer, and stands about 25 percent shorter than our comparable modular stacks for safety and convenience in the laboratory.

“Rather than making incremental improvements to UHPLC, we have designed this platform from the ground up, including the columns,” said Fraser McLeod, vice president and general manager, HPLC, Thermo Fisher Scientific. “The result is a system that combines advantages in separations performance, sample throughput, ease-of-use, reproducibility and method transfer efficiency.”

Columns Designed Specifically to Optimize Vanquish System Performance

Central to the Vanquish platform is the new family of Thermo Scientific Accucore Vanquish UHPLC columns. These columns were created specifically for the Vanquish UHPLC system to accommodate the larger power range for faster and better separations than conventional columns. The new columns feature 1.5 µm solid core particles utilizing the company’s Core Enhanced Technology to take full advantage of the Vanquish system’s 1500 bar (22,000 psi) maximum pump pressure and flow rate up to 5mL/min for short diffusion path lengths and efficient separations.

In addition, the new Thermo Scientific Acclaim UHPLC columns can be used with the Vanquish system for reversed-phase applications. The new Thermo Scientific MAbPac HIC-20 and MAbPac HIC-Butyl columns deliver added selectivity options for characterizing monoclonal antibodies.

The system also features:

> SmartFlow pumping technology designed for highly reproducible retention times and low baseline noise to enhance detection sensitivity;

> Temperature control capabilities, including direct heating and forced air temperature control modules in the column compartment, further enhancing separation efficiency and selectivity, as well as retention time reproducibility;

> Gold-standard Thermo Scientific Dionex Chromeleon Chromatography Data System, found in laboratories around the world, calibrates the system automatically and unattended. eWorkflow and Intelligent Run Control automation are designed to enhance data quality and instrument efficiency. The software features instant data reprocessing, paired with Cobra Peak Detection and Smart Link, which can speed data review significantly compared to manual procedures. Chromeleon software also supports chromatography and mass spectrometry functions simultaneously;

> Optional handheld tablet lets users conveniently monitor system status, check runs and make changes;

> Hard carbon-coated ceramic injection valve and pump pistons are designed to deliver consistent, reproducible performance for 200,000 injections, further enhancing uptime by minimizing maintenance, and;

> The system’s Diode Array Detector is designed to generate high-confidence data over a wide linear range with high signal-to-noise performance. Low-dispersion 10 mm and 60 mm flow cells can provide high sensitivity levels and wide linearity for demanding applications. Fused-silica LightPipe flow cells are designed to exploit low baseline drift for reproducible quantitation. Labs can acquire up to 10 signal channels simultaneously, and a spectrum 3D field at 200 Hz. Sensitivity, linearity, and spectral resolution can be tailored to suit the application using four programmable optical slit widths from 1 nm to 8 nm.

For high sample throughput applications, the optional Thermo Scientific Vanquish Charger is a fully integrated robotic module designed for unattended, environmentally controlled sample management and loading into the Vanquish UHPLC system. Accommodating up to nine sample racks, nine deep well plates or 20 shallow well plates, this module includes a bar code reader with empty shelf detection and rack/well plate verification. Users can add samples at any time, even while the instrument is operating, to enable maximum throughput and usability.

The new Thermo Scientific Vanquish Charged Aerosol Detector (CAD) is designed to make the near-universal detection benefits of CAD accessible at a higher speed and improved resolution, seamlessly with Vanquish UHPLC.

Please visit Pittcon booth 2523 or for more information.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $17 billion and approximately 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit



Media Contact Information:

Stu Matlow
Thermo Fisher Scientific
San Jose, Calif., USA
+1 408-965-6408

Kena Hudson
Chempetitive Group
Emeryville, Calif., USA
+1 510-908-0966

Record changed: 2016-06-07


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