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CovalX AG. (2/16/11). "Press Release: The USPTO Grants CovalX a New Patent for the Analysis of Therapeutic Protein Aggregates in the USA". Zürich.

Region Region United States (USA)
Organisations Organisation CovalX AG
  Group CovalX (Group)
  Organisation 2 US Patent and Trademark Office (USPTO)
  Group United States (govt)
Products Product MALDI technology
  Product 2 mass spectrometry solution/method

The United States Patent and Trademark Office (USPTO) has granted a US Patent (12/448.313) to CovalX AG (Schlieren), claiming for a new method to characterize therapeutic protein aggregates based on MALDI mass spectrometry.

The method of the invention allows the direct analysis of therapeutic protein aggregqates in a very broad mass range (currently up to 2 MDa) with nM sensitivity. The method can be applied in most formulation buffers and allows to characterize the stoechiometry and the ratios of the aggregates detected.

The method takes benefits of specially developed cross-linking molecules, allowing fast and efficient stabilization of the aggregates and a unique high-mass detection system allowing nM detection of the complexes up to 2 MDa.

The patented method is currently used in CovalX CRO laboratory and help pharmaceutical and biotechnology companies to better understand their therapeutic proteins.

Record changed: 2016-03-19


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